郭莲仙
出生年月:1984年5月,
卫生检验学教授,硕士生导师
学习经历:
2001.9-2005.6:华中农业大学,全日制生物工程本科;
2005.7-2007.7:中山大学,生物技术,全日制硕士研究生;
2007.9-2010.7:中山大学,生物技术,全日制博士研究生。
工作经历:
2010.7-2012.12,学院公共卫生学院,劳动卫生与环境卫生教研室,教师
2012.12 至今, 学院公共卫生学院,卫生检验系副主任
主要科研情况:
主要研究领域是肠道微生物与宿主之间的对话机制,尤其关注食物中砷对肠道微生物的影响及微生物与宿主对砷的代谢机制,并取得了突出的成绩(成果发表于Environment International, Science of the Total Environment, Ecotoxicology and Environmental Safety等环境领域知名期刊)。近年主持各类科研课题8项,其中国家自然科学基金1项,广东省自然科学基金3项,广东省优秀青年教师培养计划项目1项,东莞市科技计划重点项目3项;发表SCI/EI收录论文20篇,获得授权发明专利2项。Environment International、Science of the Total Environment、Chemosphere等杂志审稿人。
具体科研情况
(1)_主持科研项目(课题)及人才计划项目情况:
[1] 广东省自然科学基金-面上项目:2020A1515010457,冬虫夏草生活史中砷的生物转化研究,10万元,在研,广东省科技厅
[2] 广东省自然科学基金-自由申请:2018A030313094,肠道微生物解砷毒机制的研究,10万元,在研,广东省科技厅
[3] 东莞市社会发展项目:20185071521641, 肠道菌群中砷解毒微生物菌剂的筛选与定植研究,18万元,在研,主持
[4] 广东省高等学校优秀青年教师培养计划:YQ2015084,冬虫夏草发生率与寄主内外环境微生态关系的研究,30万元,在研,主持
[5] 广东省自然科学基金面上项目:2014A030313538,环境微生态结构影响冬虫夏草寄主染菌机制的研究
[6] 国家自然科学基金青年基金项目:81303155,冬虫夏草寄主蝠蛾染菌机制的新研究
(2)近年来以第一作者或通讯作者发表的科研论文:
[1]Liu, Y.#, Shi, M.#, Liu, X., Xie, J., Yang, R., Ma, Q., Guo, L.* (2021). Arsenic transfer along the soil-sclerotiu-stroma chain in Chinese cordyceps and the related health risk assessment. PeerJ 9:e11023 (IF2020=2.379)
[2]Guo L., Dou X., Zou R., et al. The mycobiome in murine intestine is more perturbed by food arsenic exposure than in excreted feces (2021). Science of The Total Environment, 141871. (IF=6.551)
[3]Liu, Y.#, Xie, J.#, Ma, Q., Zhang, G., Yu, H., Guo, L.* (2020). Levels of Pb, Ni, As, and Cd in habitat soils of Chinese Cordyceps in the Shergyla Mountain, Tibet, Toxicological & Environmental Chemistry. 102. (IF2020=1.05)
[4]Wang, J., Zhang, G., Lin, Z., Luo, Y., Fang, H., Yang, L., Guo, L.* (2020). Determination of arsenicals in mouse tissues after simulated exposure to arsenic from rice for sixteen weeks and the effects on histopathological features. Ecotoxicology and Environmental Safety, 200. (IF2020=4.872)
[5]Liu, X., Zhao, X., Wang, Y., Hong, J., Shi, M., Pfaff, D., Guo, L.*, Tang, H*. (2020) Triphenyl phosphate permeates the blood brain barrier and induces neurotoxicity in mouse brain. Chemosphere. 252. (IF=5.108)
[6]Wang, J., Hu, W., Yang, H., Chen, F., Shu, Y., Zhang, G., Liu, J., Liu, Y., Li, H., Guo, L.*(2020). Arsenic concentrations, diversity and co-occurrence patterns of bacterial andfungal communities in the feces of mice under sub-chronic arsenic exposurethrough food. Environment International. 138: 105600. (IF=7.943)
[7]王琛绯,石明,王佳婷等. 食物慢性砷暴露对小鼠脑组织中砷形态的影响,现代食品科技, 2020(36).(中文核心期刊,通讯作者)
[8]王佳婷, 方衡, 杨林洁,等. 大米中的砷形态对小鼠各组织中砷代谢分布及其病理特征的影响. 现代食品科技, 2020(4).(中文核心期刊,通讯作者)
[9]Liang, Y., Hong, Y., Mai, Z., Zhu, Q.,Guo, L.*(2019). Internal and external microbial community of the thitarodes moth, the host of ophiocordyceps sinensis. Microorganisms, 7(11). (IF=4.167)
[10]Shao, J., Lai, B., Jiang, W., Wang, J., Hong, Y., Chen, F., …Guo, L.*(2019). Diversity and co-occurrence patterns of soil bacterial and fungal communities of chinese cordyceps habitats at shergyla mountain, tibet: Implications for the occurrence. Microorganisms, 7(9). (IF=4.167)
[11]Mai, Z., Lai, B., Sun, M., Shao, J.,Guo, L.* (2019). Food adulteration and traceability tests using stable carbon isotope technologies. Tropical Journal of Pharmaceutical Research. University of Benin. (IF=3.098)
[12]Li Y.#, Guo L.#, Zhou Q., et al. Characterization of Humic Substances in the Soils of Ophiocordyceps sinensis Habitats in the Sejila Mountain, Tibet: Implication for the Food Source of Thitarodes Larvae[J]. Molecules, 2019, 24(2). (IF=3.060)
[13]Guo L., Zhang G., Li Q., et al. Novel Arsenic Markers for DiscriminatingWild and Cultivated Cordyceps[J]. Molecules, 2018, 23, 2804. (IF=3.098)
[14]Guo L., Zhang G., Wang J., et al. Determination of Arsenic Species in Ophiocordyceps sinensis from Major Habitats in China by HPLC-ICP-MS and the Edible Hazard Assessment[J]. Molecules, 2018, 23(5):1012. (IF=3.098)
[15]Guo L., Xu X., Hong Y., Li., Wang J. Stable carbon isotope composition of the lipids in natural Ophiocordyceps sinensis from major habitats in China and its substitutes [J]. Molecules, 2017, 22(9):1567. (IF=3.098)
[16]Guo L., Hong Y., Zhou Q., Zhu Q, Xu X., Wang J.. Fungus-larva relation in the formation of Cordyceps sinensis as revealed by stable carbon isotope analysis [J]. Scientific Reports, 2017, 7(1):7789. (IF=3998)
[17]郭莲仙, 麦展华, 赵行等. 稳定碳同位素技术在食品掺杂和溯源检测的应用. 现代食品科技, 2016(32):288-297.(中文核心期刊)
[18]Guo L., Xu X., Liang F., Yuan J., Peng J., Wu C., Wang J. Morphological Observations and Fatty Acid Composition of Indoor-Cultivated Cordyceps sinensis at a High-Altitude Laboratory on Sejila Mountain, Tibet [J]. Plos One, 2015, 10(5):e0126095. (IF=2.74)
已授权的发明专利:
[1] 一种野生冬虫夏草产品的鉴别方法(专利号:ZL 201711087915.0,第一发明人)
[2] 一种野生冬虫夏草与人工冬虫夏草的鉴别方法(专利号:ZL 201810564330.1,第一发明人)