张少杰：理学博士，广东天然药物研究与开发重点实验室教师，学院四层次引进人才，中医药防治消化道疑难病症科研创新团队PI，硕士生导师。主要从事中药/天然药物活性多糖及作用机制相关研究。近五年来，已发表SCI论文20余篇，申请发明专利6项目，授权5项。主持国家级、省部级、市厅级、校级项目6项。担任Carbohydrate Polymers, International Journal of Biological Macromolecules, Food Science and Human Wellness 等国际期刊审稿人。
部分代表作（近五年）：
[1] Shaojie Zhang*, Qian Zhang, Chong Li, Na Xing, Pengfei Zhou, Yukun Jiao*. A zinc-modified Anemarrhena asphodeloides polysaccharide complex enhances immune activity via the NF-κB and MAPK signaling pathways. International Journal of Biological Macromolecules, 2023, 249, 126017.
[2] ChongLi, Yukun Jiao, Shumin Shen, Wenchang Zhao, Qian Zhang*, Shaojie Zhang*. Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress. Biomedicine & Pharmacotherapy, 2023, 169, 115941.
[3] Shaojie Zhang*, Zhengguo Li, Xuelian Wang, Lijun An, Jiahe Bao, Jie Zhang, Jianlin Cui, Yuhao Li, Da-Qing Jin, Muhetaer Tuerhong, Munira Abudukeremu, Yasushi Ohizumi, Jing Xu*, Yuanqiang Guo*. Response surface optimization of polysaccharides from jaboticaba (Myrciaria cauliflora [Mart.] O.Berg) fruits: Ultrasound-assisted extraction, structure properties, and antioxidant/ hypoglycemic activities. Chemistry & Biodiversity, 2024, e202302070.
[4] Shaojie Zhang#, Yeling Li#, Zhengguo Li#, Wenhui Liu, Han Zhang, Yasushi Ohizumi, Akira Nakajima, Jing Xu*, Yuanqiang Guo*. Structure, anti-tumor activity, and potential anti-tumor mechanism of a fungus polysaccharide from Fomes officinalis. Carbohydrate Polymers, 2022, 296, 119794.
[5] Shaojie Zhang, Ziteng Song, Lijuan Shi, Linan Zhou, Jie Zhang, Jianlin Cui, Yuhao Li, Da-Qing Jin, Yasushi Ohizumi, Jing Xu*, Yuanqiang Guo*. A dandelion polysaccharide and its selenium nanoparticles: Structure features and evaluation of anti-tumor activity in zebrafish models. Carbohydrate Polymers, 2021, 270, 118365.
[6] Shaojie Zhang, Han Zhang, Lijuan Shi, Ying Li, Muhetaer Tuerhong, Munira Abudukeremu, Jianlin Cui, Yuhao Li, Da-Qing Jin, Jing Xu*, Yuanqiang Guo*. Structure features, selenylation modification, and improved anti-tumor activity of a polysaccharide from Eriobotrya japonica. Carbohydrate Polymers, 2021, 273, 118496.
[7] Shaojie Zhang, Lijun An, Zhengguo Li, Xuelian Wang, Honglin Wang, Lijuan Shi, Jiahe Bao, Xiaozhong Lan, Erhao Zhang, Namrita Lall, Anna-Mari Reid, Yuhao Li, Da-Qing Jin, Jing Xu*, Yuanqiang Guo*. Structural elucidation of an immunological arabinan from the rhizomes of Ligusticum chuanxiong, a traditional Chinese medicine. International Journal of Biological Macromolecules, 2021, 170, 42–52.
[8] Shaojie Zhang, Zhengguo Li, Xuelian Wang, Lijun An, Jiahe Bao, Jie Zhang, Jianlin Cui, Yuhao Li, Da-Qing Jin, Muhetaer Tuerhong, Munira Abudukeremu, Yasushi Ohizumi, Jing Xu*, Yuanqiang Guo*. Isolation, structural elucidation, and immunoregulation properties of an arabinofuranan from the rinds of Garcinia mangostana. Carbohydrate Polymers, 2020, 246, 116567.
[9] Shaojie Zhang, Lijun An, Zhengguo Li, Honglin Wang, Lijuan Shi, Jie Zhang, Yuhao Li, Da-Qing Jin, Muhetaer Tuerhong, Yasushi Ohizumi, Ling Shuai, Jing Xu*, Yuanqiang Guo*. An active heteropolysaccharide from the rinds of Garcinia mangostana Linn.: Structural characterization and immunomodulation activity evaluation. Carbohydrate Polymers, 2020, 235, 115929.
[10] Shaojie Zhang, Qi Zhang, Lijun An, Jiaojiao Zhang, Zhengguo Li, Jie Zhang, Yuhao Li, Muhetaer Tuerhong, Yasushi Ohizumi, Jing Xu*, Yuanqiang Guo*. A fructan from Anemarrhena asphodeloides Bunge showing neuroprotective and immunoregulatory effects. Carbohydrate Polymers, 2020, 229, 115477.
[11] Chunyan Yan#, Shaojie Zhang#, Changsheng Wang, Qian Zhang*. A fructooligosaccharide from Achyranthes bidentata inhibits osteoporosis by stimulating bone formation. Carbohydrate Polymers, 2019, 210, 110-118.
近三年主持项目（纵向项目）：
[1] 基于“SCFAs-Th17/Treg-NLRP3”通路探究知母治疗帕金森病的物质基础和作用机制，2024-01-01至2026-12-31，国家自然科学基金青年项目，主持；
[2] 基于“靶点钩钓-SPR”策略的知母抗衰老药效物质基础及作用机制研究，2024-01-01至2026-12-31，广东省自然科学基金面上项目，主持；
[3] 基于“靶点钩钓-分子互作”策略快速发现“半枝莲-白花蛇舌草”药对抗结肠癌的靶标蛋白及药效物质基础，2023.11.23至2026.11.22，东莞市社会发展科技项目重点项目，主持；
[4] 基于肠道菌-代谢物-免疫/炎症失衡(肠与脑)通路探究钩藤抗帕金森病的物质基础及作用机制，2024.01.01至2025.12.31，广东省中医药局科研项目面上项目，主持。
联系方式：ZhangSJ_Polymers@163.com
