朱伟导师简介（病理学技术）
一、基本情况：
朱伟，医学博士，教授，博士生导师，病理学技术教研室主任。肿瘤分子病理学研究方向，主要从事结直肠癌等恶性肿瘤分子机制及相关分子标志物研究。主持国家自然科学基金面上项目1项、广东省自然科学基金4项、广东省普通高校特色创新项目1项及学院科研项目2项。第一/通讯作者发表SCI收录论文22篇。广东省科学学与科技管理研究会医学研究专业委员会常务委员，湛江市医学会消化道肿瘤学分会第一届专业委员会常务委员，中华结直肠癌MDT联盟湛江地区分会常任委员；广东省和浙江省自然科学基金函审专家；教育部学位论文评审专家；《Molecular Therapy - Nucleic Acids》、《Theranostics》等杂志审稿专家。近3年来指导的研究生获广东省优秀研究生2人次，国家奖学金3人次，骏腾病理研究生奖学金4人次；获学院2021年度研究生教育“优秀导师”称号。
二、科研情况：
1. 近年来主持省级及以上课题：
1）广东省自然科学基金-自由申请项目，2022A1515012171，m6A修饰通过MALAT1/miR-181a-5p/eIF6/DDIT4正反馈环路调控结直肠癌机制研究，2022.01-2024.12，10万，在研。
2）广东省普通高校特色创新项目，2020KTSCX045，结直肠癌中lncRNA MALAT1胞浆/胞核异位表达受m6A修饰调控临床意义及其出核后调控分子机制研究，2020.09-2022.08，10万，在研。
3）广东省自然科学基金-自由申请项目，2020A151501303，miR-661靶向MTA1/STAT3通路调控PDCD4/ATG5影响自噬抑制CRC浸润转移及其分子机制研究，2019/09-2022/09，10万，在研。
4）国家自然科学基金面上项目，81472275，eIF6调控miR-21/PDCD4/MTA1通路促进结直肠癌侵袭转移及机制研究，2015/01-2018/12，72万，结题。
5）广东省自然科学基金-自由申请项目，2014A030313542，真核翻译起始因子eIF6靶向调控结直肠癌侵袭转移的分子机制研究，2014/10-2017/10，10万，结题。
2. 近5年来第一/通讯作者发表的主要文章：
[1] Zhu W*, Li GX*, Chen HL, Liu XY#. The role of eukaryotic translation initiation factor 6 in tumors. Oncol Lett. 2017; 14(1):3-9. (IF:1.39)
[2] Tang J, Yang Z, Wang Z, Li Z, Li H, Yin J, Deng M#, Zhu W#, Zeng C#. Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer. World J Surg Oncol. 2017; 15(1):173-177. (IF:1.6)
[3] Sun Y, Zeng C, Gan S, Li H, Cheng Y, Chen D, Li R, Zhu W#. LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer. Int J Mol Sci. 2018; 19(2):1-12. (IF: 4.183)
[4] Sun Y*, Long J*, Yin Y, Li H, Jiang E, Zeng C#, Zhu W#. Characterization of CSF2A fusion gene and its effect on EBV+ tumor cells. J Med Virol. 2018; 90(2):1750-1756. (IF: 2.049)
[5] Yin Y*, Long J*, Sun Y, Li H, Jiang E, Zeng C#, Zhu W#. The function and clinical significance of eIF3 in cancer. Gene. 2018; 673:130-133. (IF: 2.638)
[6] Long J*, Yin Y*, Guo H, Li S, Sun Y, Zeng C#, Zhu W#. The mechanisms and clinical significance of PDCD4 in colorectal cancer. Gene. 2019; 680:59-64. (IF: 2. 984)
[7] Tian F*, Zhan Y*, Zhu W*, Li J, Tang M, Chen X, Jiang J. MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2. Int J Mol Med. 2019;43(2):1058-1066. (IF: 3.098)
[8] WEI ZHU*, JIA-LI LONG*, YU-TING YIN, HAI-NA GUO, EN-PING JIANG, YU-LING LI, QING-LIAN HE, CHAO ZENG#, YAN-QIN SUN#. MicroRNA-34a suppresses the invasion and migration of colorectalcancercells by enhancing EGR1 and inhibiting vimentin. Experimental and Therapeutic Medicine. 2019; 18:2459-2466. (IF:1.785)
[9] Yuting Yin*, Jiali Long*, Qinglian He, Yuling Li, Yanqiu Liao, Peishan He, Wei Zhu#. Emerging roles of circRNA in formation and progression of cancer. Journal of Cancer. 2019; 10(21): 5015-5021. (IF: 3.565)
[10] Qinglian He*, Jiali Long*, Yuting Yin*, Yuling Li, Xue Lei, Ziqi Li, Wei Zhu#. Emerging Roles of lncRNAs in the Formation and Progression of Colorectal Cancer. Front. Oncol. 2020; 9(1542): 1-11. (IF: 6.224)
[11] Yuting Yin*, Qinglian He*, Yuling Li, Jiali Long, Xue Lei, Ziqi Li, Wei Zhu#. Emerging functions of PRKDC in the initiation and progression of cancer. Tumori J. 2020; 300891620950472. (IF: 2.098)
[12] Jiali Long*, Qinglian He*, Yuting Yin, Xue Lei, Ziqi Li, Wei Zhu#. The effect of miRNA and autophagy on colorectal cancer. Cell proliferation. 2020; 53(10): e12900. (IF: 6.831)
[13] Tian FQ*, Chen ZR*, Zhu W*, Tang MQ, Li JH, Zhang XC, Jiang J, Cheng XH. Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to Bortezomib via miR-874-3p/HDAC1 axis. J Gene Med. 2021 Feb 24:e3329. doi: 10.1002/jgm.3329. Online ahead of print. PMID: 33625798. (IF: 4.565)
[14] Xue Lei*, Qinglian He*, Ziqi Li, Qian Zou, Pingrong Xu, Haibing Yu, Yuanlin Ding, Wei Zhu#. Cancer stem cells in colorectal cancer and the association with chemotherapy resistance. Medical Oncology. 2021;38:43. (IF: 3.064)
[15] Qinglian He, Ziqi Li, Jinbao Yin, Yuling Li, Yuting Yin, Xue Lei and Wei Zhu#. Prognostic significance of autophagy relevant gene markers in colorectal cancer. Front. Oncol. 2021; 11(1542): 1-11. (IF: 6.224)
[16] Qinglian He, Aihua Ye, Weibiao Ye, Xiaomin Liao, Guoqiang Qin, Yongqiang Xu, Yuting Yin, Huanqian Luo, Muhua Yi, Liying Xian, Shihao Zhang, Xiyuan Qin, Wei Zhu# and Yuling Li#. Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1. Cell Death & Disease. 2021;12:576. (IF: 8.469)
[17] Qinglian He*, Ziqi Li, Xue Lei, Qian Zou, Haibing Yu, Yuanlin Ding, Guangxian Xu, and Wei Zhu#. The underlying molecular mechanisms and prognostic factors of RNA binding protein in colorectal cancer: A study based on multiple online databases. Cancer Cell International. 2021;21:325 (IF: 5.722)
3.授权专利：
(1) 发明人：朱伟；专利名称：一种细胞划痕用装置；授权时间：2021-2-19；专利号：ZL202020550541.2，中国。
电子邮箱：zhuwei@gdmu.edu.cn联系电话：13528679285（微信）
